Liposomal NAD+: Buzz, Benefits & What You Should Know Before You Sip
- MaryNell Goolsby
- 4 days ago
- 4 min read
Ever wonder if there’s a supplement that could boost your energy, sharpen your thinking, and help you age with a little more grace? Liposomal NAD+ is making waves—and while the science is still catching up, the potential is pretty exciting. In this post, Honey breaks down what it is, how it stacks up to other well-loved supplements, and what to watch for if you decide to give it a try. Because informed is fabulous—and feeling your best is the real flex. 💪🍯

🧬 Liposomal NAD+: What’s the Buzz & Is It Worth It?
Hey y’all — Honey here! 🍯
Let’s talk about something that’s been lighting up conversations lately in the world of supplements and longevity: Liposomal NAD+. It’s being praised for everything from sharper thinking to slowing down aging—but is it all hype, or is there real science behind it?
In my position as Director of Operations managing a medical practice, I spend a lot of time around clinicians and health-conscious patients. While I’m not a clinician myself, I’m incredibly passionate about exploring the latest health trends and sharing what I learn with you—so you can feel more empowered to have meaningful conversations with your medical provider.
This post is meant to educate and inspire—not to diagnose or treat. But if you’re like me and you want to live longer, stronger, and with a vibrant, clear mind, let’s dive in…
🧬 What is Liposomal NAD+?
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell of our body. It plays a critical role in:
🧠 Cellular energy production
🔧 DNA repair
🔄 Metabolic function
🔋 Mitochondrial health
As we age, NAD+ levels naturally decline. That drop is associated with fatigue, brain fog, and slower recovery from stress or illness.
So, what does “liposomal” mean?
💧 Liposomal supplements use tiny fat-like bubbles—called liposomes—to wrap around the active ingredient, like NAD+. This protective coating helps the nutrients travel through your digestive system without being broken down too quickly.
That means:
✔️ Enhanced absorption
✔️ More efficient delivery into your cells
While liposomal nutrients can be incorporated into capsules or powders, they’re most often found in liquid or gel form, which is believed to work more harmoniously with the body’s complex digestive process—offering a smoother, more effective way to absorb key nutrients.
🔬 How Does It Compare to Other Well-Studied Supplements?
Supplement | What It Does | Evidence Strength |
Liposomal NAD+ | Supports energy, aging, brain function (still under research) | 🔄 Promising but early |
Omega-3s (DHA/EPA) | Brain, heart, joint health; mood support | ✅ Strong, long-term data |
Lion’s Mane Mushroom | Supports nerve growth and memory | ⚠️ Emerging but encouraging |
Vitamin B Complex | Supports energy, nervous system, and brain clarity | ✅ Strong clinical support |
CoQ10 (Ubiquinol) | Mitochondrial and heart health, especially in older adults | ✅ Well-studied |
Curcumin (w/ black pepper) | Anti-inflammatory, antioxidant, may support aging well | ✅ Good evidence |
⚠️ Things to Know
Liposomal NAD+ has been shown to be generally safe, but long-term data in humans is still being collected.
It’s not a magic bullet—but it may be a helpful addition to a healthy lifestyle.
Basics such as sleep, whole-food nutrition, movement, and stress reduction remain your best foundation for aging well.
💡 Final Thoughts
If you’re curious about NAD+, liposomal forms offer a more effective way to try it than standard pills. But let’s think of it as an extra layer of support, not a replacement for proven essentials. Combining it with Omega-3s, B vitamins, CoQ10, and lifestyle upgrades may help you feel your best as you age gracefully and vibrantly.
📋 How to Monitor If NAD+ Is Working for You
NAD+ supplements don’t always have instant effects—but small improvements may build over 4–8 weeks. Here’s what to track:
🧠 Mental & Cognitive Clarity
More mental alertness during the day?
Less brain fog or forgetfulness?
⚡ Energy & Recovery
More physical energy, especially midday?
Better recovery after exercise?
😴 Sleep Quality
Falling asleep more easily?
Waking more refreshed?
💪 Mood & Motivation
Feeling more emotionally balanced or upbeat?
More inclined to move your body or plan your day?
🩺 Suggested Monitoring & Follow-Up
To track your progress, consider:
Wellness journal: Rate sleep, energy, mood, and focus (1–10 scale)
Check-in at 4–6 weeks: Any noticeable changes?
Optional labs to discuss with your healthcare provider:
Vitamin B12, folate, homocysteine
CRP or ESR (inflammation markers)
CoQ10 levels (if supplementing)
And of course, schedule a follow-up if you’re unsure whether to continue.
⚠️ When to Pause or Discontinue
Stop using NAD+ and talk to your doctor if you experience:
Headaches or insomnia
Fatigue that worsens
Jitters or GI discomfort
🐝 In Summary — From Honey
I’m endlessly fascinated by the tools we have to age with grace and grit. Supplements like NAD+ might be part of that journey—but only when used mindfully and with guidance. My goal is always to offer information that helps you feel empowered, not overwhelmed.
If this post sparked your curiosity, let it be the start of a deeper conversation with your healthcare provider. You deserve to feel good in your body and confident in your care.
With love and liposomes,
Honey (MaryNell) 🍯